Neurovirological correlation with HIV-associated neurocognitive disorders and encephalitis in a HAART-era cohort.

ABSTRACT:

Objective

Replicating HIV-1 in the brain is present in HIV encephalitis (HIVE) and microglial nodule encephalitis (MGNE) and is putatively linked with HIV-associated neurocognitive disorders (HAND). A cliniconeurovirological correlation was conducted to elucidate the relationship between brain viral load and clinical phenotype. SUBJECTS AND ASSAYS: HIV gag/pol RNA and DNA copies were quantified with reverse transcriptase-polymerase chain reaction or polymerase chain reaction in 148 HAART-era brain specimens. Comparison with HAND, HIVE, and MGNE and correlation with neuropsychological (NP) test scores were done using one-way ANOVA with Tukey-Kramer and Spearman tests, respectively.

Results

Brain HIV RNA was higher in subjects with HAND plus HIVE versus without HAND (delta = 2

SUBMITTER: Gelman BB 

PROVIDER: S-EPMC3664102 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature