Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data.

ABSTRACT:

Objectives

Obesity as measured by body mass index (BMI) is one of the major risk factors for osteoarthritis. In addition, genetic overlap has been reported between osteoarthritis and normal adult height variation. We investigated whether this relationship is due to a shared genetic aetiology on a genome-wide scale.

Methods

We compared genetic association summary statistics (effect size, p value) for BMI and height from the GIANT consortium genome-wide association study (GWAS) with genetic association summary statistics from the arcOGEN consortium osteoarthritis GWAS. Significance was evaluated by permutation. Replication of osteoarthritis association of the highlighted signals was investigated in an independent dataset. Phenotypic information of height and BMI was accounted

SUBMITTER: Elliott KS 

PROVIDER: S-EPMC3664369 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature