UK vaccination schedule: persistence of immunity to hepatitis B in children vaccinated after perinatal exposure.

ABSTRACT:

Objective

To assess persistence of immunity to hepatitis B (HBV) in primary school children vaccinated following perinatal exposure.

Design

Serological survey.

Setting

Five UK sites (Berkshire East, Birmingham, Buckinghamshire, Milton Keynes and Oxfordshire).

Participants

Children from 3 years 4 months to 10 years of age (mean age 6.2 years), vaccinated against HBV from birth following perinatal exposure.

Interventions

A single booster dose of the paediatric formulation of a recombinant HBV vaccine.

Main outcome measures

Titres of antibody against hepatitis B Surface Antigen (anti-HBs) measured immediately before and 21-35 days after the HBV vaccine booster.

Results

Prebooster anti-HBs titres were >10 mIU/ml in 84.6% of children (n=26; 95%

SUBMITTER: Yates TA 

PROVIDER: S-EPMC3664378 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature