Disease-associated miRNA-mRNA networks in oral lichen planus.

ABSTRACT:

Background

A large number of pathophysiological mechanisms are regulated by microRNAs (miRNAs), which represent a new class of posttranscriptional regulators of gene expression. To date, little is known about their role in oral lichen planus (OLP), a chronic inflammatory mucocutaneous disease of unknown etiology which is being discussed as a potentially premalignant condition of oropharyngeal cancer. The aim of the present investigation was to assess the pathophysiological impact of miRNAs and to determine regulatory miRNA networks which are directly linked to potentially disease-associated target transcripts in OLP.

Methods

Native tissue samples were collected from the oral mucosa of seven patients with OLP. The control group was composed of native tissue from elective oral

SUBMITTER: Gassling V 

PROVIDER: S-EPMC3664564 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature