Association between HIF1A P582S and A588T polymorphisms and the risk of urinary cancers: a meta-analysis.

ABSTRACT:

Purpose

The hypoxia-inducible factor-1 alpha (HIF1A) plays a vital role in cancer initiation and progression. Previous studies have reported the existence of HIF1A P582S and A588T missense polymorphisms in renal, urothelial and prostatic carcinomas, however the effects remain conflicting. Therefore, we performed a meta-analysis to assess the association between these sites and the susceptibility of urinary cancers.

Methods

We searched the PubMed database without limits on language until Nov 25, 2012 for studies exploring the relationship of HIF1A P582S and A588T polymorphisms and urinary cancers. Still, article search was supplemented by screening the references of retrieved studies manually. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate

SUBMITTER: Li D 

PROVIDER: S-EPMC3664576 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature