Metformin vs insulin in the management of gestational diabetes: a meta-analysis.

ABSTRACT:

Background

Nowadays, there have been increasing studies comparing metformin with insulin. But the use of metformin in pregnant women is still controversial, therefore, we aim to examine the efficiency and safety of metformin by conducting a meta-analysis of randomized controlled trials (RCTs) comparing the effects of metformin with insulin on glycemic control, maternal and neonatal outcomes in gestational diabetes mellitus (GDM).

Methods

We used the key words "gestational diabetes" in combination with "metformin" and searched the databases including Pubmed, the Cochrane Library, Web of knowledge, and Clinical Trial Registries. A random-effects model was used to compute the summary risk estimates.

Results

Meta-analysis of 5 RCTs involving 1270 participants detected tha

SUBMITTER: Gui J 

PROVIDER: S-EPMC3664585 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature