Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence.

ABSTRACT:

Context

There are no effective pharmacotherapies for stimulant dependence but there are many plausible targets for development of novel therapeutics. We hypothesized that dopamine-related targets are relevant for treatment of stimulant dependence, and there will likely be individual differences in response to dopaminergic challenges.

Objective

To measure behavioral and brain functional markers of drug-related attentional bias in stimulant-dependent individuals studied repeatedly after short-term dosing with dopamine D(2)/D(3) receptor antagonist and agonist challenges.

Design

Randomized, double-blind, placebo-controlled, parallel-groups, crossover design using pharmacological functional magnetic resonance imaging.

Setting

Clinical research unit (GlaxoSmithKline

SUBMITTER: Ersche KD 

PROVIDER: S-EPMC3664786 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature