Spontaneous behavioral responses in the orofacial region: a model of trigeminal pain in mouse.

ABSTRACT:

Objectives

To develop a translational mouse model for the study and measurement of non-evoked pain in the orofacial region by establishing markers of nociceptive-specific grooming behaviors in the mouse.

Background

Some of the most prevalent and debilitating conditions involve pain in the trigeminal distribution. Although there are current therapies for these pain conditions, for many patients, they are far from optimal. Understanding the pathophysiology of pain disorders arising from structures innervated by the trigeminal nerve is still limited, and most animal behavioral models focus on the measurement of evoked pain. In patients, spontaneous (non-evoked) pain responses provide a more accurate representation of the pain experience than do responses that are evoked by an a

SUBMITTER: Romero-Reyes M 

PROVIDER: S-EPMC3664930 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature