Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells.

ABSTRACT:

Background & aims

Early embryogenesis involves cell fate decisions that define the body axes and establish pools of progenitor cells. Development does not stop once lineages are specified; cells continue to undergo specific maturation events, and changes in gene expression patterns lead to their unique physiological functions. Secretory pancreatic acinar cells mature postnatally to synthesize large amounts of protein, polarize, and communicate with other cells. The transcription factor MIST1 is expressed by only secretory cells and regulates maturation events. MIST1-deficient acinar cells in mice do not establish apical-basal polarity, properly position zymogen granules, or communicate with adjacent cells, disrupting pancreatic function. We investigated whether MIST1 directly induc

SUBMITTER: Direnzo D 

PROVIDER: S-EPMC3664941 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature