Genome-wide linkage and follow-up association study of postpartum mood symptoms.

ABSTRACT:

Objective

Family studies have suggested that postpartum mood symptoms might have a partly genetic etiology. The authors used a genome-wide linkage analysis to search for chromosomal regions that harbor genetic variants conferring susceptibility for such symptoms. The authors then fine-mapped their best linkage regions, assessing single nucleotide polymorphisms (SNPs) for genetic association with postpartum symptoms.

Method

Subjects were ascertained from two studies: the NIMH Genetics Initiative Bipolar Disorder project and the Genetics of Recurrent Early-Onset Depression. Subjects included women with a history of pregnancy, any mood disorder, and information about postpartum symptoms. In the linkage study, 1,210 women met criteria (23% with postpartum symptoms), and 417 micr

SUBMITTER: Mahon PB 

PROVIDER: S-EPMC3665341 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature