Dose escalation for locally advanced lung cancer using adaptive radiation therapy with simultaneous integrated volume-adapted boost.

ABSTRACT:

Purpose

To test the feasibility of a planned phase 1 study of image-guided adaptive radiation therapy in locally advanced lung cancer.

Methods and materials

Weekly 4-dimensional fan beam computed tomographs (4D FBCT) of 10 lung cancer patients undergoing concurrent chemoradiation therapy were used to simulate adaptive radiation therapy: After an initial intensity modulated radiation therapy plan (0-30 Gy/2 Gy), adaptive replanning was performed on week 2 (30-50 Gy/2 Gy) and week 4 scans (50-66 Gy/2 Gy) to adjust for volume and shape changes of primary tumors and lymph nodes. Week 2 and 4 clinical target volumes (CTV) were deformably warped from the initial planning scan to adjust for anatomical changes. On the week 4 scan, a simultaneous integrated volume-adapted boost was c

SUBMITTER: Weiss E 

PROVIDER: S-EPMC3665644 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature