Phenethylisothiocyanate alters site- and promoter-specific histone tail modifications in cancer cells.

ABSTRACT: Site-specific histone modifications are important epigenetic regulators of gene expression. As deregulation of genes often results in complex disorders, corrective modulation of site-specific histone marks could be a powerful therapeutic or disease-preventive strategy. However, such modulation by dietary compounds and the resulting impact on disease risk remain relatively unexplored. Here we examined phenethylisothiocyanate (PEITC), a common dietary compound derived from cruciferous vegetables with known chemopreventive properties under experimental conditions, as a possible modulator of histone modifications in human colon cancer cells. The present study reports novel, dynamic, site-specific chemical changes to histone H3 in a gene-promoter-specific manner, associated with PEITC exposure

SUBMITTER: Liu Y 

PROVIDER: S-EPMC3665791 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature