An overview of STRUCTURE: applications, parameter settings, and supporting software.

ABSTRACT:

Objectives

We present an up-to-date review of STRUCTURE software: one of the most widely used population analysis tools that allows researchers to assess patterns of genetic structure in a set of samples. STRUCTURE can identify subsets of the whole sample by detecting allele frequency differences within the data and can assign individuals to those sub-populations based on analysis of likelihoods. The review covers STRUCTURE's most commonly used ancestry and frequency models, plus an overview of the main applications of the software in human genetics including case-control association studies (CCAS), population genetics, and forensic analysis. The review is accompanied by supplementary material providing a step-by-step guide to running STRUCTURE.

Methods

With reference to a w

SUBMITTER: Porras-Hurtado L 

PROVIDER: S-EPMC3665925 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature