Use of antihypotensive therapies in extremely preterm infants.

ABSTRACT:

Objective

To investigate the relationships among blood pressure (BP) values, antihypotensive therapies, and in-hospital outcomes to identify a BP threshold below which antihypotensive therapies may be beneficial.

Methods

Prospective observational study of infants 23(0/7) to 26(6/7) weeks' gestational age. Hourly BP values and antihypotensive therapy use in the first 24 hours were recorded. Low BP was investigated by using 15 definitions. Outcomes were examined by using regression analysis controlling for gestational age, the number of low BP values, and illness severity.

Results

Of 367 infants enrolled, 203 (55%) received at least 1 antihypotensive therapy. Treated infants were more likely to have low BP by any definition (P < .001), but for the 15 definitions of low

SUBMITTER: Batton B 

PROVIDER: S-EPMC3666108 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature