The effect of pulsatile loading and scaffold structure for the generation of a medial equivalent tissue engineered vascular graft.

ABSTRACT: A reliable and cost-effective scaffold for tissue-engineered vascular graft that would not only support cell proliferation and growth but also maintain cell phenotype has been a long-term challenge. In this study, we propose a biodegradable and biomimetic copolymer of gelatin with vinyl acetate synthesized via a graft copolymerization technique to generate tubular scaffolds for vascular tissue engineering. Two fabrication techniques, freeze drying and electrospinning, were used to generate the differing architectures for the scaffolds and characterized. The electrospun scaffolds were found to have a faster rate of mass loss in physiological saline of 81.72% within 4 months compared with 60% mass loss for the freeze-dried samples, though the materials were more crystalline. Vascular (v) smo

SUBMITTER: Thomas LV 

PROVIDER: S-EPMC3666261 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature