Pneumonia and pneumonia related mortality in patients with COPD treated with fixed combinations of inhaled corticosteroid and long acting β2 agonist: observational matched cohort study (PATHOS).

ABSTRACT:

Objective

To investigate the occurrence of pneumonia and pneumonia related events in patients with chronic obstructive pulmonary disease (COPD) treated with two different fixed combinations of inhaled corticosteroid/long acting β2 agonist.

Design

Observational retrospective pairwise cohort study matched (1:1) for propensity score.

Setting

Primary care medical records data linked to Swedish hospital, drug, and cause of death registry data for years 1999-2009.

Participants

Patients with COPD diagnosed by a physician and prescriptions of either budesonide/formoterol or fluticasone/salmeterol.

Main outcome measures

Yearly pneumonia event rates, admission to hospital related to pneumonia, and mortality.

Results

9893 patients were eligible for matching

SUBMITTER: Janson C 

PROVIDER: S-EPMC3666306 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature