TMEM16A/ANO1 channels contribute to the myogenic response in cerebral arteries.

ABSTRACT:

Rationale

Pressure-induced arterial depolarization and constriction (the myogenic response) is a smooth muscle cell (myocyte)-specific mechanism that controls regional organ blood flow and systemic blood pressure. Several different nonselective cation channels contribute to pressure-induced depolarization, but signaling mechanisms involved are unclear. Similarly uncertain is the contribution of anion channels to the myogenic response and physiological functions and mechanisms of regulation of recently discovered transmembrane 16A (TMEM16A), also termed Anoctamin 1, chloride (Cl(-)) channels in arterial myocytes.

Objective

To investigate the hypothesis that myocyte TMEM16A channels control membrane potential and contractility and contribute to the myogenic response in cerebra

SUBMITTER: Bulley S 

PROVIDER: S-EPMC3666568 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature