A rationally designed A34R mutant oncolytic poxvirus: improved efficacy in peritoneal carcinomatosis.

ABSTRACT: Oncolytic poxviruses have demonstrated initial promising results in patients with cancer in clinical trials, yet further improvements are needed. It has been shown that a single point mutation in the A34R gene resulted in the production of more total progeny virus and more extracellular enveloped virus (EEV), a form that can be immune-evasive and with enhanced spread. We have genetically engineered a new oncolytic poxvirus (designated vA34R) by incorporating this mutated A34R gene into a viral backbone (vvDD) which was designed for tumor-selective replication. This rationally designed virus can evade neutralization from antipoxvirus antibodies and is highly cytotoxic to cancer cells. It demonstrates improved spread and increased replication within the peritoneal cavity resulting in improve

SUBMITTER: Thirunavukarasu P 

PROVIDER: S-EPMC3666626 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature