Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity.

ABSTRACT: The development of neural circuits relies on spontaneous electrical activity that occurs during immature stages of development. In the developing mammalian auditory system, spontaneous calcium action potentials are generated by inner hair cells (IHCs), which form the primary sensory synapse. It remains unknown whether this electrical activity is required for the functional maturation of the auditory system. We found that sensory-independent electrical activity controls synaptic maturation in IHCs. We used a mouse model in which the potassium channel SK2 is normally overexpressed, but can be modulated in vivo using doxycycline. SK2 overexpression affected the frequency and duration of spontaneous action potentials, which prevented the development of the Ca(2+)-sensitivity of vesicle fusion

SUBMITTER: Johnson SL 

PROVIDER: S-EPMC3666720 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature