Dietary uptake of Wedelia chinensis extract attenuates dextran sulfate sodium-induced colitis in mice.

ABSTRACT:

Scope

Traditional medicinal herbs are increasingly used as alternative therapies in patients with inflammatory diseases. Here we evaluated the effect of Wedelia chinensis, a medicinal herb commonly used in Asia, on the prevention of dextran sulfate sodium (DSS)-induced acute colitis in mice. General safety and the effect of different extraction methods on the bioactivity of W. chinensis were also explored.

Methods and results

C57BL/6 mice were administrated hot water extract of fresh W. chinensis (WCHF) orally for one week followed by drinking water containing 2% DSS for nine days. WCHF significantly attenuated the symptoms of colitis including diarrhea, rectal bleeding and loss of body weight; it also reduced the shortening of colon length and histopathological damage cause

SUBMITTER: Huang YT 

PROVIDER: S-EPMC3667021 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature