A method of 2D/3D registration of a statistical mouse atlas with a planar X-ray projection and an optical photo.

ABSTRACT: The development of sophisticated and high throughput whole body small animal imaging technologies has created a need for improved image analysis and increased automation. The registration of a digital mouse atlas to individual images is a prerequisite for automated organ segmentation and uptake quantification. This paper presents a fully-automatic method for registering a statistical mouse atlas with individual subjects based on an anterior-posterior X-ray projection and a lateral optical photo of the mouse silhouette. The mouse atlas was trained as a statistical shape model based on 83 organ-segmented micro-CT images. For registration, a hierarchical approach is applied which first registers high contrast organs, and then estimates low contrast organs based on the registered high contrast

SUBMITTER: Wang H 

PROVIDER: S-EPMC3667217 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature