Genome-wide association of single-nucleotide polymorphisms with weight loss outcomes after Roux-en-Y gastric bypass surgery.

ABSTRACT:

Context

Roux-en-Y gastric bypass (RYGB) is among the most effective treatments for extreme obesity and obesity-related complications. However, despite its potential efficacy, many patients do not achieve and/or maintain sufficient weight loss.

Objective

Our objective was to identify genetic factors underlying the variability in weight loss outcomes after RYGB surgery.

Design

We conducted a genome-wide association study using a 2-stage phenotypic extreme study design.

Setting

Patients were recruited from a comprehensive weight loss program at an integrated health system.

Patients

Eighty-six obese (body mass index >35 kg/m(2)) patients who had the least percent excess body weight loss (%EBWL) and 89 patients who had the most %EBWL at 2 years after surgery

SUBMITTER: Rinella ES 

PROVIDER: S-EPMC3667258 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature