Epigenetic therapy in lung cancer.

ABSTRACT: Epigenetic deregulation of gene function has been strongly implicated in carcinogenesis and is one of the mechanisms contributing to the development of lung cancer. The inherent reversibility of epigenetic alterations makes them viable therapeutic targets. Here, we review the therapeutic implications of epigenetic changes in lung cancer, and recent advances in therapeutic strategies targeting DNA methylation and histone acetylation.

SUBMITTER: Liu SV 

PROVIDER: S-EPMC3667274 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature