Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.

ABSTRACT:

Background

The response to treatment for asthma is characterized by wide interindividual variability, with a significant number of patients who have no response. We hypothesized that a genomewide association study would reveal novel pharmacogenetic determinants of the response to inhaled glucocorticoids.

Methods

We analyzed a small number of statistically powerful variants selected on the basis of a family-based screening algorithm from among 534,290 single-nucleotide polymorphisms (SNPs) to determine changes in lung function in response to inhaled glucocorticoids. A significant, replicated association was found, and we characterized its functional effects.

Results

We identified a significant pharmacogenetic association at SNP rs37972, replicated in four independent p

SUBMITTER: Tantisira KG 

PROVIDER: S-EPMC3667396 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature