Alternative splicing in the regulation of cholesterol homeostasis.

ABSTRACT:

Purpose of review

With the advent of whole-transcriptome sequencing, or RNA-seq, we now know that alternative splicing is a generalized phenomenon, with nearly all multiexonic genes subject to alternative splicing. In this review, we highlight recent studies examining alternative splicing as a modulator of cellular cholesterol homeostasis and as an underlying mechanism of dyslipidemia.

Recent findings

A number of key genes involved in cholesterol metabolism are known to undergo functionally relevant alternative splicing. Recently, we have identified coordinated changes in alternative splicing in multiple genes in response to alterations in cellular sterol content. We and others have implicated several splicing factors as regulators of lipid metabolism. Furthermore, a number

SUBMITTER: Medina MW 

PROVIDER: S-EPMC3667406 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature