A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice.

ABSTRACT:

Objective

A sexual dimorphism exists in body fat distribution; females deposit relatively more fat in subcutaneous/inguinal depots whereas males deposit more fat in the intra-abdominal/gonadal depot. Our objective was to systematically document depot- and sex-related differences in the accumulation of adipose tissue and gene expression, comparing differentially expressed genes in diet-induced obese mice with mice maintained on a chow diet.

Research design and methods

We used a microarray approach to determine whether there are sexual dimorphisms in gene expression in age-matched male, female or ovariectomized female (OVX) C57/BL6 mice maintained on a high-fat (HF) diet. We then compared expression of validated genes between the sexes on a chow diet.

Results

After expo

SUBMITTER: Grove KL 

PROVIDER: S-EPMC3667412 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature