Amoxicillin for acute rhinosinusitis: a randomized controlled trial.

ABSTRACT:

Context

Evidence to support antibiotic treatment for acute rhinosinusitis is limited, yet antibiotics are commonly used.

Objective

To determine the incremental effect of amoxicillin treatment over symptomatic treatments for adults with clinically diagnosed acute rhinosinusitis.

Design, setting, and participants

A randomized, placebo-controlled trial of adults with uncomplicated, acute rhinosinusitis were recruited from 10 community practices in Missouri between November 1, 2006, and May 1, 2009.

Interventions

Ten-day course of either amoxicillin (1500 mg/d) or placebo administered in 3 doses per day. All patients received a 5- to 7-day supply of symptomatic treatments for pain, fever, cough, and nasal congestion to use as needed.

Main outcome measures

Th

SUBMITTER: Garbutt JM 

PROVIDER: S-EPMC3667493 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature