Examination of nuclear receptor expression in osteoblasts reveals Rorβ as an important regulator of osteogenesis.

ABSTRACT: A complex network of transcription factors contributes to the establishment and maintenance of the osteoblastic phenotype. Although relatively few transcription factors, such as Runx2 and osterix, are essential to the process of osteoblastic differentiation, others serve the purpose of fine-tuning in response to various environmental and hormonal cues. The nuclear receptor (NR) superfamily of transcription factors are involved in numerous aspects of bone biology. In this study, we characterized the expression pattern of the entire NR superfamily in differentiating primary murine calvarial cells in order to identify novel NR regulatory patterns. Dynamic patterns of NR expression were observed throughout the differentiation process. Interestingly, retinoic acid receptor-related orphan recept

SUBMITTER: Roforth MM 

PROVIDER: S-EPMC3667501 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature