Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.

ABSTRACT:

Importance

Genetic variants associated with susceptibility to late-onset Alzheimer disease are known for individuals of European ancestry, but whether the same or different variants account for the genetic risk of Alzheimer disease in African American individuals is unknown. Identification of disease-associated variants helps identify targets for genetic testing, prevention, and treatment.

Objective

To identify genetic loci associated with late-onset Alzheimer disease in African Americans.

Design, setting, and participants

The Alzheimer Disease Genetics Consortium (ADGC) assembled multiple data sets representing a total of 5896 African Americans (1968 case participants, 3928 control participants) 60 years or older that were collected between 1989 and 2011 at multiple

SUBMITTER: Reitz C 

PROVIDER: S-EPMC3667653 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature