Association between response to albendazole treatment and β-tubulin genotype frequencies in soil-transmitted helminths.

ABSTRACT:

Background

Albendazole (ABZ), a benzimidazole (BZ) anthelmintic (AH), is commonly used for treatment of soil-transmitted helminths (STHs). Its regular use increases the possibility that BZ resistance may develop, which, in veterinary nematodes is caused by single nucleotide polymorphisms (SNPs) in the β-tubulin gene at positions 200, 167 or 198. The relative importance of these SNPs varies among the different parasitic nematodes of animals studied to date, and it is currently unknown whether any of these are influencing BZ efficacy against STHs in humans. We assessed ABZ efficacy and SNP frequencies before and after treatment of Ascaris lumbricoides, Trichuris trichiura and hookworm infections.

Methods

Studies were performed in Haiti, Kenya, and Panama. Stool samples were ex

SUBMITTER: Diawara A 

PROVIDER: S-EPMC3667785 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature