Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial.

ABSTRACT:

Objective

To investigate the validity of recommendations in treatment guidelines to use higher than approved doses of oseltamivir in patients with severe influenza.

Design

Double blind randomised trial.

Setting

Thirteen hospitals in Indonesia, Singapore, Thailand, and Vietnam.

Participants

Patients aged ≥ 1 year admitted to hospital with confirmed severe influenza.

Interventions

Oral oseltamivir at double dose (150 mg twice a day/paediatric equivalent) versus standard dose (75 mg twice a day/paediatric equivalent).

Main outcome measure

Viral status according to reverse transcriptase polymerase chain reaction (RT-PCR) for influenza RNA in nasal and throat swabs on day five.

Results

Of 326 patients (including 246 (75.5%) children aged <15), 1

SUBMITTER: South East Asia Infectious Disease Clinical Research Network 

PROVIDER: S-EPMC3668094 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature