Synthesis, characterization, in vitro antimicrobial, and U2OS tumoricidal activities of different coumarin derivatives.

ABSTRACT:

Background

Coumarin and its derivatives are biologically very active. It was found that the enhanced activities are dependent on the coumarin nucleus. Biological significance of these compounds include anti-bacterial, anti-thrombotic and vasodilatory, anti-mutagenic, lipoxygenase and cyclooxygenase inhibition, scavenging of reactive oxygen species, and anti-tumourigenic. Our interest in medicinal chemistry of dicoumarol compounds have been developed by keeping in view the importance of coumarins along with its derivatives in medicinal chemistry. All the synthesized compounds were fully characterized by spectroscopic and analytical techniques and were screened for antimicrobial and U2OS bone cancer activities.

Results

4-hydroxycoumarin was derivatized by condensing with diffe

SUBMITTER: Rehman S 

PROVIDER: S-EPMC3668295 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature