Structure prediction and analysis of DNA transposon and LINE retrotransposon proteins.

ABSTRACT: Despite the considerable amount of research on transposable elements, no large-scale structural analyses of the TE proteome have been performed so far. We predicted the structures of hundreds of proteins from a representative set of DNA and LINE transposable elements and used the obtained structural data to provide the first general structural characterization of TE proteins and to estimate the frequency of TE domestication and horizontal transfer events. We show that 1) ORF1 and Gag proteins of retrotransposons contain high amounts of structural disorder; thus, despite their very low conservation, the presence of disordered regions and probably their chaperone function is conserved. 2) The distribution of SCOP classes in DNA transposons and LINEs indicates that the proteins of DNA transpo

SUBMITTER: Abrusan G 

PROVIDER: S-EPMC3668768 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature