Ontology highlight
ABSTRACT:
SUBMITTER: Banck MS
PROVIDER: S-EPMC3668835 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20130515 6
Small intestine neuroendocrine tumors (SI-NETs) are the most common malignancy of the small bowel. Several clinical trials target PI3K/Akt/mTOR signaling; however, it is unknown whether these or other genes are genetically altered in these tumors. To address the underlying genetics, we analyzed 48 SI-NETs by massively parallel exome sequencing. We detected an average of 0.1 somatic single nucleotide variants (SNVs) per 106 nucleotides (range, 0-0.59), mostly transitions (C>T and A>G), which sugg ...[more]