Pericytes derived from adipose-derived stem cells protect against retinal vasculopathy.

ABSTRACT:

Background

Retinal vasculopathies, including diabetic retinopathy (DR), threaten the vision of over 100 million people. Retinal pericytes are critical for microvascular control, supporting retinal endothelial cells via direct contact and paracrine mechanisms. With pericyte death or loss, endothelial dysfunction ensues, resulting in hypoxic insult, pathologic angiogenesis, and ultimately blindness. Adipose-derived stem cells (ASCs) differentiate into pericytes, suggesting they may be useful as a protective and regenerative cellular therapy for retinal vascular disease. In this study, we examine the ability of ASCs to differentiate into pericytes that can stabilize retinal vessels in multiple pre-clinical models of retinal vasculopathy.

Methodology/principal findings

We found

SUBMITTER: Mendel TA 

PROVIDER: S-EPMC3669216 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature