The myxovirus resistance A (MxA) gene -88G>T single nucleotide polymorphism is associated with prostate cancer.

ABSTRACT:

Background

Myxovirus (influenza virus) resistance A (MxA) is an interferon stimulated antiviral protein that is required for a complete antiviral response. MxA polymorphism (rs2071430) is located within an Interferon Stimulated Response Element (ISRE) at position -88 in the gene's promoter region, and it has been associated with increased susceptibility to infections and various diseases. In general, the low promoter activity genotype (GG) promotes susceptibility, whereas the high promoter activity genotype (TT) confers protection to Hepatitis C viral infection. MxA's role in prostate cancer is not fully understood. Previous literature has shown that MxA may be a mediator of the effect of IFN on normal and tumor cell motility. MxA may act as a tumor suppressor and the level of expr

SUBMITTER: Glymph S 

PROVIDER: S-EPMC3669225 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature