Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed.

ABSTRACT:

Background

Anthrax and its etiologic agent remain a biological threat. Anthrax vaccine is highly effective, but vaccine-induced IgG antibody responses vary widely following required doses of vaccinations. Such variation can be related to genetic factors, especially genomic copy number variants (CNVs) that are known to be enriched among genes with immunologic function. We have tested this hypothesis in two study populations from a clinical trial of anthrax vaccination.

Methods

We performed CNV-based genome-wide association analyses separately on 794 European Americans and 200 African-Americans. Antibodies to protective antigen were measured at week 8 (early response) and week 30 (peak response) using an enzyme-linked immunosorbent assay. We used DNA microarray data (Affymetri

SUBMITTER: Falola MI 

PROVIDER: S-EPMC3669407 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature