Association of galanin and major depressive disorder in the Chinese Han population.

ABSTRACT:

Objective

This study aimed to investigate the association of galanin (GAL) gene and the development of depression in the Chinese Han population.

Methods

A total of 700 patients with depression who met the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) and 673 healthy controls were used in this study. Ligase detection reactions were performed on 10 selected single nucleotide polymorphism (SNP) sites in the GAL gene. A series of statistical methods were carried out to investigate the correlation between the GAL gene SNP and the patient susceptibility to depression.

Results

The SNPs of rs694066 in the GAL gene showed a positive correlation with MDD. Compared with the healthy controls, lower frequency of G/G genotype

SUBMITTER: Wang YJ 

PROVIDER: S-EPMC3669409 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature