Genetic association study of mitochondrial polymorphisms in neovascular age-related macular degeneration.

ABSTRACT:

Purpose

Age-related macular degeneration (AMD) is a multifactorial disease involving genetic and environmental factors. Most of the genetic factors identified so far involve the nuclear genome. Recently, two studies in North America and Australia reported an association between advanced AMD and the mitochondrial T2 haplogroup. Our purpose was to assess this association in a large French population.

Methods

This case control study included 1,224 patients with neovascular AMD and 559 controls with normal fundus. Mitochondrial DNA polymorphisms at and around nucleotides 4917, 11,812, and 14,233 were determined using PCR amplification and direct sequencing of mitochondrial DNA.

Results

No association was found between the mitochondrial T2 haplogroup and neovascular AMD in

SUBMITTER: Tilleul J 

PROVIDER: S-EPMC3669531 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature