Association of insulin and insulin-like growth factors with Barrett's oesophagus.

ABSTRACT:

Background

It is postulated that high serum levels of insulin and insulin growth factor 1 (IGF-1) mediate obesity-associated carcinogenesis. The relationship of insulin, IGF-1 and IGF binding proteins (IGFBP) with Barrett's oesophagus (BO) has not been well examined.

Methods

Serum levels of insulin and IGFBPs in patients with BO were compared with two separate control groups: subjects with gastro-oesophageal reflux disease (GORD) and screening colonoscopy controls. Fasting insulin, IGF-1 and IGFBPs were assayed in the serum of BO cases (n = 135), GORD (n = 135) and screening colonoscopy (n = 932) controls recruited prospectively at two academic hospitals. Logistic regression was used to estimate the risk of BO.

Results

Patients in the highest tertile of serum insulin

SUBMITTER: Greer KB 

PROVIDER: S-EPMC3669672 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature