Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions.

ABSTRACT:

Purpose

Intracerebral vascular malformations including cavernous angiomas (CAs) and arteriovenous malformations (AVMs) are an important cause of chronic pharmacoresistant epilepsies. Little is known about the pathogenetic basis of epilepsy in patients with vascular malformations. Intracerebral deposits of iron-containing blood products have been generally regarded as responsible for the strong epileptogenic potential of CAs. Here, we have analyzed whether blood-brain barrier (BBB) dysfunction and subsequent astrocytic albumin uptake, recently described as critical trigger of focal epilepsy, represent pathogenetic factors in vascular lesion-associated epileptogenesis.

Methods

We examined the correlation between hemosiderin deposits, albumin accumulation, and several clinical

SUBMITTER: Raabe A 

PROVIDER: S-EPMC3669690 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature