Developmentally regulated subnuclear genome reorganization restricts neural progenitor competence in Drosophila.

ABSTRACT: Stem and/or progenitor cells often generate distinct cell types in a stereotyped birth order and over time lose competence to specify earlier-born fates by unknown mechanisms. In Drosophila, the Hunchback transcription factor acts in neural progenitors (neuroblasts) to specify early-born neurons, in part by indirectly inducing the neuronal transcription of its target genes, including the hunchback gene. We used in vivo immuno-DNA FISH and found that the hunchback gene moves to the neuroblast nuclear periphery, a repressive subnuclear compartment, precisely when competence to specify early-born fate is lost and several hours and cell divisions after termination of its transcription. hunchback movement to the lamina correlated with downregulation of the neuroblast nuclear protein, Distal ant

SUBMITTER: Kohwi M 

PROVIDER: S-EPMC3670710 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature