Gene expression analysis distinguishes tissue-specific and gender-related functions among adult Ascaris suum tissues.

ABSTRACT: Over a billion people are infected by Ascaris spp. intestinal parasites. To clarify functional differences among tissues of adult A. suum, we compared gene expression by various tissues of these worms by expression microarray methods. The A. suum genome was sequenced and assembled to allow generation of microarray elements. Expression of over 40,000 60-mer elements was investigated in a variety of tissues from both male and female adult worms. Nearly 50 percent of the elements for which signal was detected exhibited differential expression among different tissues. The unique profile of transcripts identified for each tissue clarified functional distinctions among tissues, such as chitin binding in the ovary and peptidase activity in the intestines. Interestingly, hundreds of gender-specifi

SUBMITTER: Wang Z 

PROVIDER: S-EPMC3670759 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature