Expression of pro- and anti-angiogenic factors during the formation of the periocular vasculature and development of the avian cornea.

ABSTRACT:

Background

During embryonic development, endothelial precursor cells (angioblasts) migrate relatively long distances to form the primary vascular plexus. The migratory behavior of angioblasts and localization of the primitive blood vessels is tightly regulated by pro-angiogenic and anti-angiogenic factors encountered in the embryonic environment. Despite the importance of corneal avascularity to proper vision, it is not known when avascularity is established in the developing cornea and how pro- and anti-angiogenic factors regulate this process.

Results and discussion

Using Tg(tie1:H2B:eYFP) transgenic quail embryos to visualize fluorescently labeled angioblasts, we show that the presumptive cornea remains avascular despite the invasion of cells from the periocular region wh

SUBMITTER: Kwiatkowski S 

PROVIDER: S-EPMC3671393 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature