Characterizing protein domain associations by Small-molecule ligand binding.

ABSTRACT:

Background

Protein domains are evolutionarily conserved building blocks for protein structure and function, which are conventionally identified based on protein sequence or structure similarity. Small molecule binding domains are of great importance for the recognition of small molecules in biological systems and drug development. Many small molecules, including drugs, have been increasingly identified to bind to multiple targets, leading to promiscuous interactions with protein domains. Thus, a large scale characterization of the protein domains and their associations with respect to small-molecule binding is of particular interest to system biology research, drug target identification, as well as drug repurposing.

Methods

We compiled a collection of 13,822 physical interac

SUBMITTER: Li Q 

PROVIDER: S-EPMC3671605 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature