Racial differences in bone mineral density and fractures in men receiving androgen deprivation therapy for prostate cancer.

ABSTRACT:

Purpose

Whether race influences bone loss and fracture risk during androgen deprivation therapy for prostate cancer is unknown. Using data from a prospective clinical trial we compared bone mineral density and fracture between African-American and Caucasian men receiving androgen deprivation therapy.

Materials and methods

A total of 516 subjects were in the placebo group of a 2-year randomized placebo controlled fracture prevention trial, and were African-American (68) or Caucasian (448). We compared baseline characteristics, changes in bone mineral density and rates of new fractures between races.

Results

Compared to Caucasian men, African-American men had higher baseline hip bone mineral density (mean ± SD 0.98 ± 0.15 vs 0.91 ± 0.15 gm/m(2), p = 0.001) and similar s

SUBMITTER: Morgans AK 

PROVIDER: S-EPMC3671868 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature