Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study.

ABSTRACT:

Objective

To examine a 1-year follow-up of a 4-month, controlled clinical trial of exercise and antidepressant medication in patients with major depressive disorder (MDD).

Methods

In the original study, 202 sedentary adults with MDD were randomized to: a) supervised exercise; b) home-based exercise; c) sertraline; or d) placebo pill. We examined two outcomes measured at 1-year follow-up (i.e., 16 months post randomization): 1) continuous Hamilton Depression Rating Scale score; and 2) MDD status (depressed; partial remission; full remission) in 172 available participants (85% of the original cohort). Regression analyses were performed to examine the effects of treatment group assignment, as well as follow-up antidepressant medication use and self-reported exercise (Godin Leis

SUBMITTER: Hoffman BM 

PROVIDER: S-EPMC3671874 | biostudies-literature | 2011 Feb-Mar

REPOSITORIES: biostudies-literature