FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior.

ABSTRACT: Patients with epilepsy are at high risk for major depression relative to the general population, and both disorders are associated with changes in adult hippocampal neurogenesis, although the mechanisms underlying disease onset remain unknown. The expression of fosB, an immediate early gene encoding FosB and ΔFosB/Δ2ΔFosB by alternative splicing and translation initiation, is known to be induced in neural progenitor cells within the subventricular zone of the lateral ventricles and subgranular zone of the hippocampus, following transient forebrain ischemia in the rat brain. Moreover, adenovirus-mediated expression of fosB gene products can promote neural stem cell proliferation. We recently found that fosB-null mice show increased depressive behavior, suggesting impaired neurogenesis in fo

SUBMITTER: Yutsudo N 

PROVIDER: S-EPMC3672000 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature