Molecular mechanisms of anti-tumor properties of P276-00 in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Tumors of the head and neck present aggressive pathological behavior in patients due to high expression of CDK/CCND1 proteins. P276-00, a novel CDK inhibitor currently being tested in clinic, inhibits growth of several cancers in vitro and in vivo. The pre clinical activity of P276-00 in head and neck cancer and its potential mechanisms of action at molecular level are the focus of the current studies.

Method

We have investigated the anti-cancer activity of P276-00 in head and neck tumors in vitro and in vivo. Candidate gene expression profiling and cell based proteomic approaches were taken to understand the pathways affected by P276-00 treatment.

Results

It was observed that P276-00 is cytotoxic across various HNSCC cell lines with an IC₅₀ ranging from 1.

SUBMITTER: Mishra PB 

PROVIDER: S-EPMC3672051 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature