Effect of tumor microenvironment on tumor VEGF during anti-VEGF treatment: systems biology predictions.

ABSTRACT:

Background

Vascular endothelial growth factor (VEGF) is known to be a potent promoter of angiogenesis under both physiological and pathological conditions. Given its role in regulating tumor vascularization, VEGF has been targeted in various cancer treatments, and anti-VEGF therapy has been used clinically for treatment of several types of cancer. Systems biology approaches, particularly computational models, provide insight into the complexity of tumor angiogenesis. These models complement experimental studies and aid in the development of effective therapies targeting angiogenesis.

Methods

We developed an experiment-based, molecular-detailed compartment model of VEGF kinetics and transport to investigate the distribution of two major VEGF isoforms (VEGF121 and VEGF165) in

SUBMITTER: Finley SD 

PROVIDER: S-EPMC3672077 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature